A recent review considers a potential link between unexpected drug toxicities and patient adherence in clinical trials and asks: how safe is the prescribed dose for some drugs now on
In the mid-1990s, physicians in the US noticed that some of their patients who had been taking an oral hypoglycemic unexpectedly began developing signs of toxicity. The only thing that had changed was that these patients had received a disease management programme six months earlier to encourage them to stay in therapy and take the dose as prescribed.
The cause of these unexpected toxicities was perplexing because these patients were taking the same approved dose as they had been taking before the education programme. The pharmaceutical company distributing the programme attributed the increased sales during this time period to increased adherence.
Years later, patients suddenly developed unexpected side- effects from prescription drugs that had been on the market for five to ten years. Rofecoxib (Vioxx), which had been approved in 1999, was withdrawn from the market in 2004, while Valdecoxib (Bextra), approved in 2001, was withdrawn in 2005.
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Consumer Health Information Corporation was founded by Dorothy L. Smith, Pharm.D, an internationally recognized clinical pharmacist with expertise in patient adherence and patient education. The mission of Consumer Health Information Corporation is to help patients learn how to manage their diseases and prescribed treatments safely and wisely. The company has developed more than 4000 evidence-based patient education programs for medications, medical devices, disease management and Phase III clinical trials worldwide. A respected clinical and educational source, Consumer Health Information Corporation has won major national and international awards for excellence in patient and consumer education programs that have significantly increased patient adherence. Dr. Smith is the author of more than 130 professional articles, 23 books and has delivered more than 150 professional and scholarly addresses.
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