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The Truth About Osteoporosis and Hormones
By Janelle L. Gustinucci, Doctor of Pharmacy
Candidate
University of Pittsburgh School of Pharmacy
Pittsburgh, PA
Osteoporosis
is the most common bone disease that will increase the chance
of having a broken bone. About 4-6 million women in the United
States have it and it is a common disease that mostly affects
women over the age of 50. Half of the women in this age group
will have a broken bone due to osteoporosis in their lifetime.
Anyone can develop osteoporosis but women who have reached menopause
have the highest risk of getting this disease. Other common risks
include small body size, having Caucasian or Asian heritage, drinking
too much alcohol, smoking cigarettes, a diet low in calcium and
vitamin D, and being on certain medicines for a long time like
steroids (such as prednisone). The first signs you can see are
often "shrinking" or having a bone break easily. There
are tests that can measure how solid your bones are. If you are
not sure whether or not you have osteoporosis, talk to you doctor
to find out if these tests are right for you.
What is HRT?
If you are a woman who has reached menopause, your body does not
make enough of an important hormone called estrogen. This can
lead to osteoporosis and bone loss. Hormone replacement therapy
(HRT) is the phrase used when a woman takes hormone pills that
contain estrogen or the combination of estrogen/progesterone after
menopause. There are two types of HRT. Most women who have had
a hysterectomy or their uterus removed use estrogen alone (Premarin®)
and women who have not had a hysterectomy would use the combined
estrogen and progesterone (Prempro®). You should not take
estrogen alone if you have not had a hysterectomy because it can
raise your chance of getting cancer in the lining of your uterus.
HRT can relieve the symptoms of menopause (such as hot flashes
and night sweats) and lower the risk of osteoporosis, colon and
rectal cancer. They are the most common hormones prescribed to
women past menopause.
What are the problems with HRT?
Recently, using hormones to prevent osteoporosis has been found
to have serious, and much talked about, side effects. There has
been a lot of questions since a study published in the Journal
of the American Medical Association in July 2002 showed that
using the combined estrogen/progesterone pill for about five years
could increase the risk of breast cancer, stroke, heart attack
and blood clots. There was no increase seen in women using the
product that contained only estrogen. The study with the combined
hormone pill was stopped early because of these risks.
Many women use HRT for a short time to treat
the symptoms of menopause. If you have been using it for 2-3 years,
studies have not found a link to breast cancer, stroke, heart
attack and blood clots. There are other options you can try and
you can always talk to your doctor about them.
Women who are taking the combined hormone for
osteoporosis should talk to their doctors about stopping this
medicine. It is important to know that you should not stop taking
the pill on your own. Your doctor will talk with you about the
other options available. If you are stopping HRT, there are other
medicines that help stop your bones from breaking down. Some examples
of these are Fosamax®, Evista® and many more. Your doctor
will help you decide which is best for you depending on your health
history.
What are my other options?
There are many choices besides HRT to prevent or treat osteoporosis.
This advice is important for all women, not only those over the
age of 50. Taking care of your bones as early as your 20's can
help prevent problems later. Some important things to remember
that will help protect your bones:
- Keep physically active with weight bearing exercises such
as walking, jogging, dancing or light weight lifting (be sure
to contact you doctor before starting any exercise program).
- Take a Calcium + Vitamin D supplement (ask your doctor or
pharmacist what dose is right for you)
- Eat foods that have a lot of calcium: low-fat dairy food,
salmon, sardines, dark-green leafy vegetables and calcium-rich
orange juice
- Your body makes enough vitamin D by spending 20 minutes a
day in the sun. You can also eat foods that have a lot of vitamin
D: eggs, sardines, salmon, liver, cereal and milk.
- Quit smoking
- Limit the amount of alcohol you drink
Important Questions to Ask
It is important to remember that if you have been taking the combined
estrogen/progesterone pill to prevent osteoporosis you need to
talk with your doctor about stopping this medicine. Here are some
questions you might want to ask:
- Why am I taking HRT?
- Have I been taking the combined hormone pill?
- Should I stop taking it and if so, how?
- Is there something else I can use for osteoporosis? What are
the side effects of these other options?
- Should I have a mammogram?
Remember, your healthcare providers are available
to help answer your questions, so be sure to contact them if you
have any questions.
National Osteoporosis foundation website: http://www.nof.org
© 2003 Consumer Health Information Corporation. All rights reserved.

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